Patrick Maxeiner (DOD: 1/06/2000)
Patrick Maxeiner was just shy of his 25th birthday in January of 2000. At 24 years old, he was 6 months into pursuing a combined masters/PhD at the University of Michigan and already a published author of a scientific paper (see link below), a member of the Phi Beta Kappa Honor Society, a Big Brother and on the University's Bass Fishing Team. May of 1999 marked his graduation from the University of Arizona in biochemistry and pharmacology. With a known peanut allergy, he was incredibly careful, an avid label reader. This lean guy, who was described as one who 'ate to live', likely perished from cross-contamination of a frozen dinner produced by a company that ran 2 lines - one that made peanut containing food and one that did not.
His friend and neighbor recalled the smell of cooking coming from Patrick's apartment around 11p or 12a. This late night meal was fairly typical for him. Next, the neighbor heard EMS breaking through his door at 5:30a or 6a. Likely sensing a reaction, Patrick had tried a few 'home remedies' including Benadryl. He had suffered intense vomiting. Patrick had called EMS in the early morning hours requesting help for an allergic reaction. Upon arrival, he was breathing but it was described as labored. EMS was able to obtain an airway but it was difficult and Patrick perished 3 days later.
He had a known peanut allergy. In the past, with an accidental ingestion, he had wheezing and intense vomiting. He was under the care of an allergist but he and his family were not told to carry an epinephrine auto-injector to their knowledge. He was able to eat almonds with tolerance. Patrick had asthma and allergic rhinitis, which was notably better while he studied in Arizona. He had been through allergy shots. Patrick had been admitted to a hospital in the past for asthma but never for food allergies.
Patrick was a guy who loved fishing and golf. After graduation from the University of Arizona, he and friend 'fished' there way back to the mid-west. He was described as 'amazing'.
Methylation of the BRCA1 promoter is associated with decreased BRCA1 mRNA levels in clinical breast cancer specimens
Carcinogenesis, Volume 21, Issue 9, 1 September 2000, Pages 1761–1765,https://doi.org/10.1093/carcin/21.9.1761
Published: 01 September 2000
Functional inactivation of BRCA1 is an important mechanism involved in breast cancer pathogenesis. Mutation is often responsible for BRCA1 inactivation in familial breast cancer, but is not responsible for the decreased levels of BRCA1 seen in a subset of sporadic breast cancer patients. To determine if aberrant cytosine methylation of the BRCA1 promoter is associated with decreased BRCA1 gene expression in human breast cancer, high resolution bisulfite sequence analysis was used to analyze the cytosine methylation status of the BRCA1promoter in 21 axillary node negative breast cancer patients with known levels of BRCA1 expression. Aberrant cytosine methylation of the BRCA1 promoter was detected in three of 21 patient specimens. These three specimens also expressed the lowest levels of BRCA1. Results from this analysis show that aberrant cytosine methylation of the BRCA1 promoter is directly correlated with decreased levels of BRCA1 expression in human breast cancer, and suggest that epigenetic silencing may be one mechanism of transcriptional inactivation of BRCA1 in sporadic mammary carcinogenesis.